1 Illustrated owner's manual
2 Animated protocols on DVD
3 Step-by-step printed protocols

If you have any additional questions, please call us at 800-684-9343 or send us an email at [email protected] . Remember, your Alpha-Stim device comes with FREE technical support. We will be happy to talk with you. Yours in health, Allevia Health Support Team.


Mon-Fri 9:00AM - 5:00PM PST
Tel: 1-800-684-9343

Alpha-Stim vs. Other Treatments

Comparison with other electromedical modalities

In contrast to other electromedical treatments of psychological and psychiatric disorders, CES utilizes very mild, low-frequency currents often below sensory thresholds in most patients. Unlike Deep Brain Stimulation (DBS) or Vagus Nerve Stimulation (VNS), CES does not require surgical implantation of electrodes and is therefore substantially less expensive and safer. A very low incidence of side effects (usually mild and self-limiting) and a high clinical efficacy make CES an attractive modality that should be considered a first-line medical treatment for anxiety, depression or insomnia in many patients.

Modality Indications Mechanism (treatment parameters) Regulation
Alpha-Stim CES Anxiety, insomnia, depression Induction of an alpha state and modulation of electrocortical activity with mild electrical currents to relieve symptoms (< 1mA, 0.5 or 100Hz) Clinical use
(Transcranial Magnetic Stimulation)
Severe depression, mania, PTSD, OCD, chronic pain Modulation of electrocortical activity with electrical currents in the brain generated with a strong external magnetic field. Clinical use
(Vagus Nerve Stimulation)
Epilepsy, refractory depression Stimulation with surgically implanted electrodes to relieve symptoms Clinical use
(Deep Brain Stimulation)
Parkinson’s disease, essential tremor, dystonia Stimulation with surgically implanted electrodes to relieve symptoms Clinical use
(Electroconvulsive therapy)
Severe depression, mania, schizophrenia Induction of a bilateral tonic-clonic seizure under anesthesia to relieve symptoms (120-225V, 500-800mA, 30-70Hz). Clinical use


CES vs. antidepressants: an analysis of treatment efficacy

The following analysis compares the efficacy of leading selective serotonin reuptake inhibitors (Prozac, Paxil, Zoloft, Celexa) and serotonin-norepinephrine reuptake inhibitors (Effexor, Serzone) with that of cranial electrotherapy stimulation (CES). The cited drug efficacy information is based on the data reported to the FDA by the manufacturers of the respective brands as part of their new drug application process. CES efficacy data come from studies submitted to the FDA by the manufacturer of the Alpha-Stim®, Electromedical Products International, Inc. as part of a regulatory 515(i) reclassification process for CES.


The results of this comparison suggest that CES may represent a stronger modality for the treatment of depression than antidepressants given its high average effect size (63%), which can be interpreted as the additional amount of clinical improvement beyond the benefits (effects) of placebo. The comparative average value for antidepressants appears to be only 21%. See Gilula and Kirsch (2005) for more information.


Alpha-Stim vs. competing CES devices


Unparalleled, State-of-the-Art Technology

  • Alpha-Stim uses a patented microcurrent waveform in all of its device models.
  • Like a unique chemical ingredient in a drug, it is the electrical waveform that distinguishes one electromedical product from another. As a result, no other CES device can replicate our efficacy and safety.
  • Our latest models feature a slew of new features that make them highly reliable and user friendly.

The Most Researched Device in its Class

The efficacy and safety of Alpha-Stim is backed by more independent research than there is for all other CES devices combined.

Other devices use our research to promote their own products. Please keep in mind, however, that since Alpha-Stim uses a very unique (patented) waveform delivered with earclip electrodes, the unparalleled treatment outcomes and safety achieved by our devices simply cannot be replicated by other products.

The Most Recommended CES Device in the World

For more than three decades, Alpha-Stim has been the gold standard of CES. Millions of patients have been treated with our devices worldwide.

Alpha-Stim is significantly effective for 9 out of 10 people who use it.

We Use Safe, Low-Frequency Signals

Alpha-Stim utilizes ultra-low (0.5Hz) frequencies during current delivery in CES.

Only minor, self-limiting side effects have been reported from the use of our products, with the most common being headaches (0.10%) and skin reactions at the electrode sites (0.07%).

We Use Earclips for Discreet and Comfortable Treatments

Our approach to current delivery is very simple and highly reliable. There is no dripping mess or need for expensive sponges or other accessories.

You can use Alpha-Stim in the privacy of your home, in the office, or the road. The possibilities are limitless.

Pay as You Go

In contrast to competitors, we offer flexible rent-to-own plants.

Instead of buying a CES device upfront, you can choose to rent an Alpha-Stim device for $100/month with no penalties or extra fees. Learn more

Backed by a 5-Year Warranty

Our devices include a comprehensive manufacturer peace of mind warranty. Shorter, 1-year warranties are typical for other medical devices.

FREE Clinical and Technical Support for Life

All of our devices include unparalleled free clinical and technical support via phone or email.

You can ask as many questions as you like and we are always happy to offer assistance.

You always talk to a real person.

Millions have experienced the benefits of Alpha-Stim.

  • Thank you for making such a great product available to those of us who struggle with anxiety and are looking for treatment with something other than traditional medicines. It really does work.
    Cindy Wilson // Columbus, OH

Kirsch, Daniel L. (2002). The Science Behind Cranial Electrotherapy Stimulation, 2nd Edition, Medical Scope Publishing Corporation, Edmonton, Alberta, Canada, 224 pp.
Smith, Ray B. (2001). Is microcurrent stimulation effective in pain management? An additional perspective. American Journal of Pain Management 11(2):62-66.
Gilula, M. F. and D. L. Kirsch (2005). Cranial electrotherapy stimulation review: a safer alternative to psychopharmaceuticals in the treatment of depression. Journal of Neurotherapy 9(2): 7-26.
Kirsch et al. (2002). The emperor's new drugs: an analysis of antidepressant medication data submitted to the FDA. Prevention and Treatment, 5:1-11.
Bianco, F. (1994). The efficacy of cranial electrotherapy stimulation (CES) for the relief of anxiety and depression among polysubstance abusers in chemical dependency treatment. Ph.D. Dissertation. University of Tulsa.
Krupitsky et al. (1991). The administration of transcranial electric treatment for affective disturbances therapy in alcoholic patients. Drug and Alcohol Dependence 27(1):1-6.
Lichtbroun et al. (2001). The treatment of fibromyalgia with cranial electrotherapy stimulation. Journal of Clinical Rheumatology 7(2):72-78.
Matteson, M. T., and J. M. Ivancevich (1986). An exploratory investigation of CES as an employee stress management technique. Journal of Health and Human Resource Administration 9:93-109.
Rosenthal, S. H. (1972). Electrosleep: a double-blind clinical study. Biological Psychiatry 4(2):179-185.
Rosenthal, S. H. and N. L. Wulfsohn (1970). Electrosleep: a preliminary communication. Journal of Nervous and Mental Disease 151:146-151.
Smith et al. (1994). The use of cranial electrotherapy stimulation in the treatment of closed-head-injured patients. Brain Injury 8(4):357-361.
Smith, R. B., and L. O’Neil (1975). Electrosleep in the management of alcoholism. Biological Psychiatry 10(6):675-680.