1 Illustrated owner's manual
2 Animated protocols on DVD
3 Step-by-step printed protocols

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Cranial Electrotherapy Stimulation (CES)



Learn more about Alpha-Stim CES treatment protocols

— is an electromedical modality indicated for the treatment of anxiety, depression and insomnia.

“Electrosleep treatment” – an older name for CES – came into the USA from Japan in the late 1960s. This therapy had been originally pioneered in Russia and other East Block countries. Since the current was directed across head, the FDA renamed it “Cranial Electrotherapy Stimulation (CES)” in 1978, and now allows its marketing in the USA for the treatment of anxiety, depression and insomnia (CES regulatory status). A major use of CES has been in the treatment of symptoms of the drug abstinence syndrome, including severe anxiety, depression and insomnia. The medical use of CES is now becoming more widely indicated in the USA.

During a CES treatment, a mild electrical stimulus is applied transcranially with electrodes attached to the head. CES is a broad category and historically a variety of electrical devices have been used to perform this therapy. In most cases, however, the output has been limited to 1-2 mA of electrical stimulation. Modern CES devices use less than 1mA of low-frequency (0.5Hz) bi-phasic currents applied with the use of electrodes that attach to the patient’s ear lobes. An average length of treatment is generally 20-60 minutes. Daily treatments are recommended during the first 3-8 weeks of CES therapy.


Postulated mechanisms of Alpha-Stim® CES

The exact mechanism by which Alpha-Stim® produces effects is not fully known. However, based on previous and ongoing studies, it appears that the Alpha-Stim® microcurrent waveform activates particular groups of nerve cells located at the brainstem, a site at the base of the brain that sits atop of the spinal cord. These groups of nerve cells produce the chemicals serotonin and acetylcholine, which can affect the chemical activity of nerve cells that are both nearby and at more distant sites in the nervous system. In fact, these cells are situated to control the activity of nerve pathways that run up into the brain and that course down into the spinal cord.

By changing the electrical and chemical activity of certain nerve cells in the brainstem, Alpha-Stim® appears to amplify activity in some neurological systems, and diminish activity in others. This neurological ‘fine tuning’ is called modulation, and occurs either as a result of, or together with the production of a certain type of electrical activity pattern in the brain known as an alpha state which can be measured on brain wave recordings (EEG). Such alpha rhythms are accompanied by feelings of calmness, relaxation and increased mental focus. The neurological mechanisms that are occurring during the alpha state appear to decrease stress-effects, reduce agitation and stabilize mood, and control both sensations and perceptions of particular types of pain.

These effects can be produced after a single treatment, and repeated treatments have been shown to increase the relative strength and duration of these effects. In some cases, effects have been stable and permanent, suggesting that the electrical and chemical changes evoked by Alpha-Stim® have led to a durable re-tuning back to normal function.

Neurological Modulation
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Neurological Modulation

Giordano (2006) postulates that Alpha-Stim® CES engages the serotonergic (5-HT) raphe nuclei of the brainstem. 5-HT inhibits brainstem cholinergic (ACh) and noradrenergic (NE) systems that project supratentorially. This suppresses thalamo-cortical activity, arousal, agitation, alters sensory processing and induces EEG alpha rhythm.
Cortical Brain Deactivation
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Cortical Brain Deactivation

Feusner et al. (2012) suggest that Alpha-Stim CES may cause cortical brain deactivation, with a similar pattern for high- (100 Hz) and low-frequency (0.5 Hz) stimulation, and may increase or decrease connectivity within the default mode network (DMN). These effects may result from interference from high- or low-frequency noise.
Increase in Alpha Frequency Production
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Increase in Alpha Frequency Production

Kennerly (2006) has shown beneficial changes in brain activity after a single 20-minute treatment with Alpha-Stim® CES. Blue shows a decrease in delta frequency (slow brain waves) activity while red shows an increase in alpha (relaxation waves) frequency activity.

CES as a Safe and Effective Treatment for Anxiety, Insomnia and Depression

  • Results of the current [GAD] study demonstrate a significant improvement with CES, with a decrease in HARS score similar to that found in clinical trials with antidepressant and anxiolytic medications
    Bystritsky et al. (2008). Journal of Clinical Psychiatry February 6, 2008: e1-e6
  • The robust antiaggressive effects of CES report in chronically ill neuropsychiatric patients warrants publication of their findings
    Norman Sussman (2007). Editor’s Note: What next? Overcoming treatment resistance. Primary Psychiatry 14(3):15-16
  • Aggression represents the most potentially serious behavioral consequence in neuropsychiatric patients
    Norman Sussman (2007). Editor’s Note: What next? Overcoming treatment resistance. Primary Psychiatry 14(3):15-16
  • CES stimulation may result in cortical deactivation, as well as altering brain connectivity in the DMN.
    Feusner et al. (2012). Effects of cranial electrotherapy stimulation on resting state brain activity. Brain and Behavior. doi: 10.1002/brb3.45.
  • The low cost, safety, and ease of use of CES recommends its freer trial to enhance patient comfort during various routine dental procedures.
    Winick, R. L. (1999). Cranial electrotherapy stimulation (CES): a safe and effective low cost means of anxiety control in a dental practice. General Dentistry 47(1):50-55.
  • These preliminary data suggest that CES may be a reasonable alternative treatment for anxiety in persons withdrawing from alcohol or other substances while avoiding the risk of cross-tolerance and dependence that is associated with the use of benzodiazepines in this population
    James Lake, MD Nonconventional and Integrative Treatments of Alcohol and Substance Abuse. Psychiatric Times 2007; 24(6)

Cork et al. (2004). The effect of cranial electrotherapy stimulation (CES) on pain associated with fibromyalgia. The Internet Journal of Anesthesiology. Volume 8(2).
Lichtbroun et al. (2001). The treatment of fibromyalgia with cranial electrotherapy stimulation. Journal of Clinical Rheumatology, 7(2):72-78.
Brotman, P. (1989). Low-intensity transcranial electrostimulation improves the efficacy of thermal biofeedback and quieting reflex training in the treatment of classical migraine headache. American Journal of Electromedicine, 6(5):120-123.
Solomon et al. (1989). Safety and effectiveness of cranial electrotherapy in the treatment of tension headache. Headache. 29(7):445-50.
Capel et al. (2003). The amelioration of the suffering associated with spinal cord injury with subperception transcranial electrical stimulation. Spinal Cord. 41(2):109-17.
Tan et al. (2006). Using cranial electrotherapy stimulation to treat pain associated with spinal cord injury. Journal of Rehabilitation Research and Development, 43:461-474.
Alpher, E. J., and D. L. Kirsch (1998). Traumatic brain injury and full body reflex sympathetic dystrophy patient treated with cranial electrotherapy stimulation. American Journal of Pain Management, 8(4):124-128.
Kirsch, D. L. and R. B. Smith (2000b). The use of cranial electrotherapy stimulation in the management of chronic pain: a review. NeuroRehabilitation, 14(2):85-94.
Kirsch, Daniel L. (2002). The Science Behind Cranial Electrotherapy Stimulation, 2nd Edition, Medical Scope Publishing Corporation, Edmonton, Alberta, Canada, 224 pp.
James Giordano, Ph.D. (Center for Clinical Bioethics, Georgetown University Medical Center, Washington, DC).
Kennerly (2006). Changes in quantitative EEG and low resolution tomography following cranial electrotherapy stimulation. Ph.D. Dissertation, University of North Texas. 425 pp.