With more than a hundred published clinical studies, reviews, numerous case reports and post-marketing clinical surveys, Alpha-Stim® Technology, cranial electrotherapy stimulation (CES) and microcurrent electrical therapy (MET) have been firmly established as safe, effective and highly-cost effective non-pharmacological treatment modalities for anxiety, insomnia, depression and pain.
Please see below for examples of publications on CES and MET in different study-design categories.
Randomized Controlled Trials
Taylor, A. G., J. G. Anderson, S. L. Riedel, J. E. Lewis, and C. Bourguignon (2013). A randomized, controlled, double-blind pilot study of the effects of cranial electrical stimulation on activity in brain pain processing regions in individuals with fibromyalgia. Explore 9(1):32-40.
Taylor, A. G., J. G. Anderson, S. L. Riedel, J. E. Lewis, P. A. Kinser and C. Bourguignon (2011). Cranial electrical stimulation improves symptoms and functional status in individuals with fibromyalgia. Pain Management Nursing, epublished ahead of print, http://www.painmanagementnursing.org/article/S1524-9042(11)00136-6/fulltext. 2011.
Tan, G., D. H. Rintala, M. P. Jensen, J. S. Richards, S. A. Holmes, R. Parachuri, S. Lashgari-Saegh and L. R. Price (2011). Efficacy of cranial electrotherapy stimulation for neuropathic pain following spinal cord injury: a multi-site randomized controlled trial with a secondary 6-month open-label phase. The Journal of Spinal Cord Medicine 34(3):285-296.
Shultz, J. C. (2010). The effects of cranial electrotherapy stimulation on attention: A double-blinded, placebo-controlled investigation. Psy.D. Dissertation. The Chicago School of Professional Psychology, 106 pages.
Rintala, D. H., Tan, G., Willson, P., Bryant, M. S., and Lai, E. C. H. (2010). Feasibility of using cranial electrotherapy stimulation for pain in persons with Parkinson’s disease. Parkinson’s Disease. 8 pages.
Strentzsch, J. A. (2009). An examination of cranial electrotherapy stimulation (CES) on alpha-amylase levels, cortisol levels and state-trait anxiety scores in the chronically ill. Doctoral dissertation, Saint Mary’s University, San Antonio, Texas. 121 pages.
Mellen, R. R., and W. Mackey (2009). Reducing sheriff’s officers’ symptoms of depression using cranial electrotherapy stimulation (CES): a control experimental study. The Correctional Psychologist 41(1):9-15.
Mellen, R. R., and W. Mackey (2008). Cranial electrotherapy stimulation (CES) and the reduction of stress symptoms in a sheriff’s jail security and patrol officer population. American Jails 22(5):32-38.
Kim, Hyun Jung, Kim, Woon Young, Lee, Yoon Sook, Chang, Moon Seok, Kim, Jae Hwan, and Park, Young Cheo (2008). The effect of cranial electrotherapy stimulation on preoperative anxiety and hemodynamic responses. Korean Journal of Anesthesiology 55(6)657- 661.
Tan, G., Rintala, D. H., Thornby, J., Yang, J., Wade, W., and C. Vasilev. (2006).Using cranial electrotherapy stimulation to treat pain associated with spinal cord injury. Journal of Rehabilitation Research and Development 43:461-474.
Cork, R. C., P. Wood, N. Ming, C. Shepherd, J. Eddy, and L. Price (2004). The effect of cranial electrotherapy stimulation (CES) on pain associated with fibromyalgia. The Internet Journal of Anesthesiology Volume 8(2).
Sizer P., S. Sawyer, J. Brismee, K. Jones, J. Bruce, and J. Slauterbeck (2000). Texas Tech University Health Sciences Center and University Medical Center, Lubbock, Texas, USA. The effect of microcurrent stimulation on postoperative pain after patellar tendon-bone anterior cruciate ligament reconstruction. Presented at the American Physical Therapy Association Annual Conference and Exposition, Indianapolis, Indiana; June, 2000.
Voris, M. D. (1995). An investigation of the effectiveness of cranial electrotherapy stimulation in the treatment of anxiety disorders among outpatient psychiatric patients, impulse control parolees and pedophiles. Delos Mind/Body Institute, Dallas and Corpus Christi, Texas, 1995.
Overcash, S. J., and A. Siebenthall (1989). The effects of cranial electrotherapy stimulation and multisensory cognitive therapy on the personality and anxiety levels of substance abuse patients. American Journal of Electromedicine 6(2):105-111.
Brotman, P. (1989). Low-intensity transcranial electrostimulation improves the efficacy of thermal biofeedback and quieting reflex training in the treatment of classical migraine headache. American Journal of Electromedicine 6(5):120-123.
Roth, P. M., and W. J. Thrash (1986). Effect of transcutaneous electrical nerve stimulation for controlling pain associated with orthodontic tooth movement. American Journal of Orthodontics 90(2):132-138.
Open Label Clinical Trials
Liu Y. and Z. Guiqing (2011). qEEG Study on the Treatment of ADHD with CES. Chinese Journal of Clinicians (Electronic Edition) 5(8):2462-2463.
Tan, G., Dao, T. K., Smith, D. L., Robinson, A., and M. P. Jensen (2010). Incorporating complementary and alternative medicine (CAM) therapies to expand psychological services to veterans suffering from chronic pain. Psychological Services 7(3):148–161.
Tae-Kyu L., L. Kwan-Sung, J. Shin-Soo, H. Young-Kil, P. Chun-Kun, and K. Moon-Chan (2004). The control of chronic pain using microcurrent electrical therapy and cranial electrotherapy stimulation. From the Department of Neurosurgery, Kangnam St. Mary’s Hospital, College Of Medicine, and The Catholic University of Korea, Seoul, Korea. Presented at the Korea Society for Stereotactic & Functional Neurosurgery April 14, 2004.
Feusner, J., Moody, T., Hembacher, E., Madsen, S., Bookheimer, S., and A. Bystritsky (2010). Effects of cranial electrotherapy stimulation on brain activity in the resting state. Poster presented at the New Clinical Drug Evaluation Unit (NCDEU) 2010 50th Anniversary Meeting: Learning from the Past to Advance the Future of Mental Health Treatment. Co-sponsored by the National Institute of Mental Health (NIMH) and the American Society of Clinical Psychopharmacology (ASCP). June 14 – June 17, 2010 in Boca Raton, Florida.
Bystritsky, A., Moody, T., Hembacher, E., Hoffman, J., Moller, H., and J. Feusner. (2009). Effects of cranial electrotherapy stimulation on brain activity in the resting state. Poster presented at the American College of Neuropsychopharmacology (ACNP), Hollywood, Florida, December 8, 2009.
Ferdjallah, M., Bostick, F. X., Jr., and R. E. Barr (1996). Potential and current density distributions of cranial electrotherapy stimulation (CES) in a four-concentric-spheres model. IEEE Transactions on Biomedical Engineering, Vol. 43 (9), September 1996
Case Series and Case Reports
Kirsch D.L., Price L.R., Nichols F., Marksberry J.A., and K.T. Platoni (2012). Efficacy of Cranial Electrotherapy Stimulation for Anxiety, PTSD, Insomnia and Depression: US Military Service Members and Veterans Self Reports. Poster presented at the Annual Meeting of the Chinese Society of Psychiatry; co-sponsored by the Chinese Medical Association, Psychiatry Branch of the Chinese Medical Association and the Nanjing Brain Hospital. October 18-21, 2012 in Nanjing, Jiangsu Province, China.
Childs, A. (2005). Cranial electrotherapy stimulation reduces aggression in a violent retarded population: a preliminary report. The Journal of Neuropsychiatry and Clinical Neurosciences 17(4): 548-551.
Overcash, S. (2005). The effect of ROSHI protocol and cranial electrotherapy stimulation on a 9-year-old anxious, dyslexic male with attention deficit disorder: A case study. Journal of Neurotherapy 9(2):63-77.
Plotnick, S. E. (2005). Finding hope: Alpha-Stim® 100 may help clinicians yield better fibromyalgia results. Advance for Directors in Rehabilitation p. 82.
Clark, N., D. Mills, and J. Marchant (2000). Evaluation of the potential efficacy of the Alpha-Stim® SCS in the horse. DeMontfort University Equestrian Centre and Field Station, Caythorpe, Lincolnshire, United Kingdom. January, 2000.
Alpher, E. J., and D. L. Kirsch (1998). Traumatic brain injury and full body reflex sympathetic dystrophy patient treated with cranial electrotherapy stimulation. American Journal of Pain Management 8(4):124-128.
Meta-Analyses, Reviews and Commentaries
Holleran Steiker, L. K., P. Machemehl Helmly, T. Clements, and B. Earthman (2010) New and promising technologies in the field of addiction recovery: highlights of emerging expertise. Journal of Social Work Practice in the Addictions 10:331-338.
Zaghi, S., Acar, M., Hultgren, B., Boggio, S. P., and F. Fregni (2010). Noninvasive brain stimulation with low-intensity electrical currents: putative mechanisms of action for direct current and alternating current stimulation. Neuroscientist 16(3):285-307.
Tan, G., Craine, M. H. , Bair, M. J., Garcia, M. K., Giordano, J., Jensen, M. P., McDonald, S. M., Patterson, D., Sherman, R. A., Williams, W., and J. C. I. Tsao (2007). Efficacy of selected complementary and alternative medicine interventions for chronic pain. Journal of Rehabilitation Research and Development 44(2):195-222.
Tan, G., and M. P. Jensen (2007). Integrating complementary and alternative medicine (CAM) into multidisciplinary chronic pain treatment. In Multidisciplinary Chronic Pain Management: a Guidebook for Program Development and Excellence of Treatment. Schatman and Campbell (editors), Taylor & Francis, Pp. 75-99.
Kirsch, D., and M. Gilula (2007). Cranial electrotherapy stimulation in the treatment of depression: a review of the results of meta-analysis conducted on CES studies – Part 2. Practical Pain Management June 2007:32-40.
Kirsch, D., and M. Gilula (2007). CES in the treatment of anxiety disorders: statistical considerations in the meta-analysis of cranial electrotherapy stimulation (CES) treatment of anxiety disorders – Part 2. Practical Pain Management April 2007:22-39.
Kirsch, D. L., and M. Gilula (2007). CES in the treatment of anxiety disorders: A review and meta-analysis of cranial electrotherapy stimulation (CES) in the treatment of anxiety disorders – Part 1. Practical Pain Management March 2007:40-47.
Kirsch, D. L., and R. Smith (2004). Cranial electrotherapy stimulation for anxiety, depression, insomnia, cognitive dysfunction, and pain: a review and meta-analyses. In Bioelectromagnetic Medicine. Paul J. Rosch, Ed. Marcel Dekker, New York, Pp 727-740.
Kisch, D. L. (2002). The Science Behind Cranial Electrotherapy Stimulation (2nd Ed). Medical Scope Publishing Co., Edmonton, Canada, Pp. 224.
Klawansky, S., A. Yeung, C. Berkey, N. Shah, H. Phan, and T. C. Chalmers (1995). Meta-analysis of randomized controlled trials of cranial electrostimulation: efficacy in treating selected psychological and physiological conditions. Journal of Nervous and Mental Disease 183:478-485.
Kirsch, D. L. (2002). A practical protocol for electromedical treatment of pain. Chapter 61 in Pain Management: A Practical Guide for Clinicians (the textbook of the American Academy of Pain Management) edited by Richard S. Weiner, CRC Press, Boca Raton, Florida, 2002.
Kirsch, D. L. (2002). Electromedicine: the other side of physiology. Chapter 60 in Pain Management: A Practical Guide for Clinicians (the textbook of the American Acadamy of Pain Management) edited by Richard S. Weiner, CRC Press, Boca Raton, Florida, Pp 749-758, 2002.
Kirsch, D. L. (2001). Cranial electrotherapy stimulation: A practical protocol for the treatment of pain. Practical Pain Management 2(3):34-37.